«Антипролиферативное действие карнозина и его производных на опухолевые клетки нейрального происхождения ...»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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbG9tYmVyZzwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+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ADDIN EN.CITE.DATA [116]. Как только клетки входят в S фазу циклин Е деградирует и CDK2 соединяется с циклином А PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGVycjwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGVycjwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+PFJl
Y051bT4yNjA8L1JlY051bT48RGlzcGxheVRleHQ+WzgxLCAxMTBdPC9EaXNwbGF5VGV4dD48cmVj
b3JkPjxyZWMtbnVtYmVyPjI2MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF
TiIgZGItaWQ9Incyd2Z4YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MjYwPC9rZXk+
PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10
eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TaGVyciwgQy4gSi48L2F1dGhvcj48
L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFR1bW9y
IENlbGwgQmlvbG9neSwgU3QuIEp1ZGUgQ2hpbGRyZW4mYXBvcztzIFJlc2VhcmNoIEhvc3BpdGFs
LCBNZW1waGlzLCBUZW5uZXNzZWUgMzgxMDUuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+
TWFtbWFsaWFuIEcxIGN5Y2xpbnM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2VsbDwvc2Vjb25k
YXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2VsbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs
PjxmdWxsLXRpdGxlPkNlbGw8L2Z1bGwtdGl0bGU+PGFiYnItMT5DZWxsPC9hYmJyLTE+PC9wZXJp
b2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DZWxsPC9mdWxsLXRpdGxlPjxhYmJy
LTE+Q2VsbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwNTktNjU8L3BhZ2VzPjx2
b2x1bWU+NzM8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4xOTkzLzA2LzE4PC9l
ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkN5Y2xp
bnMvIHBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RzEgUGhhc2U8L2tleXdvcmQ+PGtleXdv
cmQ+TWFtbWFsczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTkzPC95ZWFyPjxw
dWItZGF0ZXM+PGRhdGU+SnVuIDE4PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDA5
Mi04Njc0IChQcmludCkmI3hEOzAwOTItODY3NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u
dW0+ODUxMzQ5MjwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1w
cm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5n
dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HcmFuYTwvQXV0aG9yPjxZZWFyPjE5
OTU8L1llYXI+PFJlY051bT4yNTk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1OTwvcmVj
LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9Incyd2Z4YWZlNnZhOXo1
ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MjU5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl
IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv
cnM+PGF1dGhvcj5HcmFuYSwgWC48L2F1dGhvcj48YXV0aG9yPlJlZGR5LCBFLiBQLjwvYXV0aG9y
PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluc3RpdHV0ZSBmb3IgQ2Fu
Y2VyIFJlc2VhcmNoIGFuZCBNb2xlY3VsYXIgQmlvbG9neSwgVGVtcGxlIFVuaXZlcnNpdHkgU2No
b29sIG9mIE1lZGljaW5lLCBQaGlsYWRlbHBoaWEsIFBBIDE5MTQwLCBVU0EuPC9hdXRoLWFkZHJl
c3M+PHRpdGxlcz48dGl0bGU+Q2VsbCBjeWNsZSBjb250cm9sIGluIG1hbW1hbGlhbiBjZWxsczog
cm9sZSBvZiBjeWNsaW5zLCBjeWNsaW4gZGVwZW5kZW50IGtpbmFzZXMgKENES3MpLCBncm93dGgg
c3VwcHJlc3NvciBnZW5lcyBhbmQgY3ljbGluLWRlcGVuZGVudCBraW5hc2UgaW5oaWJpdG9ycyAo
Q0tJcyk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+T25jb2dlbmU8L3NlY29uZGFyeS10aXRsZT48
YWx0LXRpdGxlPk9uY29nZW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt
dGl0bGU+T25jb2dlbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5PbmNvZ2VuZTwvYWJici0xPjwvcGVy
aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+T25jb2dlbmU8L2Z1bGwtdGl0bGU+
PGFiYnItMT5PbmNvZ2VuZTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIxMS05PC9w
YWdlcz48dm9sdW1lPjExPC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MTk5NS8w
Ny8yMDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5d29y
ZD5DZWxsIEN5Y2xlLyBwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkN5Y2xpbi1EZXBlbmRl
bnQgS2luYXNlcy8gYW50YWdvbmlzdHMgJmFtcDsgaW5oaWJpdG9ycy8gcGh5c2lvbG9neTwva2V5
d29yZD48a2V5d29yZD5DeWNsaW5zLyBwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkVuenlt
ZSBJbmhpYml0b3JzLyBwaGFybWFjb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+R2VuZXMsIFR1bW9y
IFN1cHByZXNzb3I8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjwva2V5d29yZHM+
PGRhdGVzPjx5ZWFyPjE5OTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdWwgMjA8L2RhdGU+PC9w
dWItZGF0ZXM+PC9kYXRlcz48aXNibj4wOTUwLTkyMzIgKFByaW50KSYjeEQ7MDk1MC05MjMyIChM
aW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT43NjI0MTM4PC9hY2Nlc3Npb24tbnVtPjx1cmxz
PjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXBy
b3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
AG==
ADDIN EN.CITE.DATA [81, 110]. Циклин А не накапливается в клетке вплоть до поздней G1 фазы из-за убиквитинирования под действием АРС. Циклины D и Е нечувствительны к действию АРС. Перед входом в S фазу Emi1, экспрессия которого запускается с помощью E2F, ингибирует АРС, способствуя стабилизации циклина А и активации СDK2. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ic3U8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ic3U8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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 EN.CITE.DATA [117].
S фаза. Основным событием S фазы является удвоение ДНК (репликация) и хроматина. Репликация может начинаться только в определенных местах – точках начала репликации (origins of replication, OR), которые разбросаны по всей ДНК. Подготовка к репликации начинает еще в конце митоза – начале G1 фазы, когда в точках начала репликации собираются т.н. пререпликационные комплексы (pre-RC), состоящие из большого количества белков необходимых для инициации репликации. Эта стадия часто называется лицензированием (licensing) точек начала репликации, т.к. синтез ДНК может происходить только в OR содержащих pre-RC. В S фазе активный комплекс циклин А/CDK2 запускает сборку преинициирующих комплексов вокруг компонентов pre-RC. Преинициирующие комплексы раскручивают спираль ДНК подготавливая место посадки ДНК, полимеразы и других ферментов репликации. Сразу после репликации OR комплекс pre-RC разбирается под действием циклин А/CDK2. Сборка новых pre-RC в S фазе невозможна из-за присутствия активных СDK, что препятствует множественной репликации PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWxsPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWxsPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA [118, 119]. Репликация хромосом состоит из репликации ДНК и репликации хроматина. Основную массу хроматина составляют белки гистоны. Циклин А/CDK2 индуцирует синтез гистонов, поставляя материал для упаковки новосинтезированной ДНК. К концу S фазы каждая хромосома состоит из двух пар идентичных сестринских хроматид. Каждая пара сестринских хроматид связана между собой комплексами белков, когезинами, которые регулируют процесс разделения сестринских хроматид при митозе ADDIN EN.CITE <EndNote><Cite><Author>Groth</Author><Year>2007</Year><RecNum>415</RecNum><DisplayText>[120]</DisplayText><record><rec-number>415</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">415</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Groth, A.</author><author>Rocha, W.</author><author>Verreault, A.</author><author>Almouzni, G.</author></authors></contributors><auth-address>Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS/Institut Curie, 26 rue d'Ulm, 75248 Paris, Cedex 5, France.</auth-address><titles><title>Chromatin challenges during DNA replication and repair</title><secondary-title>Cell</secondary-title><alt-title>Cell</alt-title></titles><periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></periodical><alt-periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></alt-periodical><pages>721-33</pages><volume>128</volume><number>4</number><edition>2007/02/27</edition><keywords><keyword>Animals</keyword><keyword>Chromatin/ genetics</keyword><keyword>DNA Repair/ genetics</keyword><keyword>DNA Replication/ genetics</keyword><keyword>Epigenesis, Genetic/ genetics</keyword><keyword>Histones/genetics/metabolism</keyword><keyword>Humans</keyword><keyword>Nucleosomes/genetics</keyword><keyword>Protein Processing, Post-Translational/genetics</keyword><keyword>Transcription Factors/metabolism</keyword></keywords><dates><year>2007</year><pub-dates><date>Feb 23</date></pub-dates></dates><isbn>0092-8674 (Print)
0092-8674 (Linking)</isbn><accession-num>17320509</accession-num><urls></urls><electronic-resource-num>10.1016/j.cell.2007.01.030</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[120].
G2 фаза. Прохождение клетки через G2 фазу и вход в митоз регулируется комплексом циклина В/CDK1 ADDIN EN.CITE <EndNote><Cite><Author>Pines</Author><Year>1989</Year><RecNum>225</RecNum><DisplayText>[121]</DisplayText><record><rec-number>225</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">225</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pines, J. </author><author>Hunter, T.</author></authors></contributors><auth-address>Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92138.</auth-address><titles><title>Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2</title><secondary-title>Cell</secondary-title><alt-title>Cell</alt-title></titles><periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></periodical><alt-periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></alt-periodical><pages>833-46</pages><volume>58</volume><number>5</number><edition>1989/09/08</edition><keywords><keyword>Amino Acid Sequence</keyword><keyword>Base Sequence</keyword><keyword>CDC2 Protein Kinase</keyword><keyword>Cell Cycle</keyword><keyword>Cloning, Molecular</keyword><keyword>DNA/genetics</keyword><keyword>Gene Expression Regulation</keyword><keyword>HeLa Cells</keyword><keyword>Humans</keyword><keyword>Mitosis</keyword><keyword>Molecular Sequence Data</keyword><keyword>Nuclear Proteins/ genetics/immunology</keyword><keyword>Phosphoproteins/metabolism</keyword><keyword>Proliferating Cell Nuclear Antigen</keyword><keyword>Protamine Kinase/metabolism</keyword><keyword>Protein Binding</keyword></keywords><dates><year>1989</year><pub-dates><date>Sep 8</date></pub-dates></dates><isbn>0092-8674 (Print)
0092-8674 (Linking)</isbn><accession-num>2570636</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[121]. На сегодняшний день семейство циклинов В состоит из 5 белков – циклины В1, В2, В3, В4 и В5, из которых В1 является наиболее охарактеризованным ADDIN EN.CITE <EndNote><Cite><Author>Ito</Author><Year>2000</Year><RecNum>472</RecNum><DisplayText>[122]</DisplayText><record><rec-number>472</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">472</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ito, M.</author></authors></contributors><auth-address>Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan.</auth-address><titles><title>Factors controlling cyclin B expression</title><secondary-title>Plant Mol Biol</secondary-title><alt-title>Plant molecular biology</alt-title></titles><periodical><full-title>Plant Mol Biol</full-title><abbr-1>Plant molecular biology</abbr-1></periodical><alt-periodical><full-title>Plant Mol Biol</full-title><abbr-1>Plant molecular biology</abbr-1></alt-periodical><pages>677-90</pages><volume>43</volume><number>5-6</number><edition>2000/11/23</edition><keywords><keyword>Animals</keyword><keyword>Base Sequence</keyword><keyword>Cell Cycle</keyword><keyword>Cyclin B/ genetics/metabolism</keyword><keyword>Cyclin-Dependent Kinases/metabolism</keyword><keyword>Gene Expression Regulation, Plant</keyword><keyword>Genes, Plant</keyword><keyword>Molecular Sequence Data</keyword><keyword>Phylogeny</keyword><keyword>Plants/ genetics/metabolism</keyword><keyword>Promoter Regions, Genetic</keyword><keyword>Sequence Alignment</keyword><keyword>Yeasts/genetics/metabolism</keyword></keywords><dates><year>2000</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0167-4412 (Print)
0167-4412 (Linking)</isbn><accession-num>11089869</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[122]. Промотор циклина В1 содержит сайты связывания для множества транскрипционных факторов, в том числе B-Myb, NF-Y, USF, p53, p21, Ap-1, Ap-2, Ets-1 и др. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UcmVtYmxleTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UcmVtYmxleTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+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ADDIN EN.CITE.DATA [123]. Экспрессия гена циклина В1 наблюдается на протяжении всего клеточного цикла, однако в G2 уровень циклина В1 в 50 раз больше, чем в G1. Наивысшего уровня циклин В1 достигает в конце G2 фазы – начале митоза ADDIN EN.CITE <EndNote><Cite><Author>Kakino</Author><Year>1996</Year><RecNum>470</RecNum><DisplayText>[124]</DisplayText><record><rec-number>470</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">470</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kakino, S.</author><author>Sasaki, K.</author><author>Kurose, A.</author><author>Ito, H.</author></authors></contributors><auth-address>Department of Neurosurgery, Yamaguchi University School of Medicine, Japan.</auth-address><titles><title>Intracellular localization of cyclin B1 during the cell cycle in glioma cells</title><secondary-title>Cytometry</secondary-title><alt-title>Cytometry</alt-title></titles><periodical><full-title>Cytometry</full-title><abbr-1>Cytometry</abbr-1></periodical><alt-periodical><full-title>Cytometry</full-title><abbr-1>Cytometry</abbr-1></alt-periodical><pages>49-54</pages><volume>24</volume><number>1</number><edition>1996/05/01</edition><keywords><keyword>Cell Cycle</keyword><keyword>Cyclin B</keyword><keyword>Cyclin B1</keyword><keyword>Cyclins/ analysis</keyword><keyword>Cytophotometry/ methods</keyword><keyword>Flow Cytometry/ methods</keyword><keyword>Glioblastoma</keyword><keyword>Humans</keyword><keyword>Neuroglia/ chemistry</keyword><keyword>Tumor Cells, Cultured</keyword></keywords><dates><year>1996</year><pub-dates><date>May 1</date></pub-dates></dates><isbn>0196-4763 (Print)
0196-4763 (Linking)</isbn><accession-num>8723902</accession-num><urls></urls><electronic-resource-num>10.1002/(sici)1097-0320(19960501)24:1<49::aid-cyto6>3.0.co;2-d</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[124]. В середине митоза уровень циклина В1 резко снижается за счет работы АРС и остается низким до поздней S фазы, когда происходит ингибирование АРС с помощью Emi1 и комплекса циклин А/CDK2 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ic3U8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ic3U8L0F1dGhvcj48WWVhcj4yMDAyPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA [117, 125]. Усиление экспрессии циклина В1 приводит к его накоплению в цитоплазме, достигнув определенной концентрации циклин В связывается с CDK1. Образовавшийся комплекс циклин В1/CDK1 перемещается в ядро PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA [126]. Транслокация циклин В1/CDK1 в ядро возможна только при фосфорилировании 5 серинов в сайте удерживающем циклин В1 в цитоплазме (cytoplasmic retention site, CRS): Ser116, Ser26, Ser128, Ser133 и Ser147 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA [126]. Показано, что ингибирование ERK1/2 препятствует фосфорилированию CRS, что приводит к удерживанию комплекса циклин В1/CDK1 в цитозоле ADDIN EN.CITE <EndNote><Cite><Author>Walsh</Author><Year>2003</Year><RecNum>490</RecNum><DisplayText>[127]</DisplayText><record><rec-number>490</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">490</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Walsh, S.</author><author>Margolis, S. S.</author><author>Kornbluth, S.</author></authors></contributors><auth-address>Duke University Medical Center, Durham, NC 27710, USA.</auth-address><titles><title>Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx</title><secondary-title>Mol Cancer Res</secondary-title><alt-title>Molecular cancer research : MCR</alt-title></titles><periodical><full-title>Mol Cancer Res</full-title><abbr-1>Molecular cancer research : MCR</abbr-1></periodical><alt-periodical><full-title>Mol Cancer Res</full-title><abbr-1>Molecular cancer research : MCR</abbr-1></alt-periodical><pages>280-9</pages><volume>1</volume><number>4</number><edition>2003/03/04</edition><keywords><keyword>Amino Acid Sequence</keyword><keyword>Animals</keyword><keyword>Cell Cycle Proteins</keyword><keyword>Cell Extracts</keyword><keyword>Cyclin B/ chemistry/ metabolism</keyword><keyword>Cyclin B1</keyword><keyword>MAP Kinase Signaling System</keyword><keyword>Mitogen-Activated Protein Kinases/ metabolism</keyword><keyword>Molecular Sequence Data</keyword><keyword>Oocytes/metabolism</keyword><keyword>Phosphorylation</keyword><keyword>Protein-Serine-Threonine Kinases/ metabolism</keyword><keyword>Serine/metabolism</keyword><keyword>Xenopus Proteins/metabolism</keyword><keyword>Xenopus laevis/metabolism</keyword></keywords><dates><year>2003</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1541-7786 (Print)
1541-7786 (Linking)</isbn><accession-num>12612056</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[127]. Yang et al. предполагают, что CRS циклина В1 является частью последовательности для экспорта белка в ядро (nuclear export sequences, NES), с помощью которой циклин В1 взаимодействует с экспортирующим ядерным рецептором (chromosome region maintenance 1, CRM1) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW5nPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW5nPC9BdXRob3I+PFllYXI+MTk5ODwvWWVhcj48UmVj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ADDIN EN.CITE.DATA [128]. Однако комплекс остается неактивным, потому что протеинкиназы Wee1 и Myt1 фосфорилируют CDK1 по Thr14 и Tyr15, ингибируя активность CDK1. Wee1 находится в ядре, а Myt1 – на цитоплазматической стороне мембраны эндоплазматического ретикулума PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb2xvbW9uPC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb2xvbW9uPC9BdXRob3I+PFllYXI+MTk5MjwvWWVhcj48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 EN.CITE.DATA [129-131]. Интересно отметить, что активация ERK1/2 снижает активность Myt1 через активацию RSK, непосредственного субстрата ERK1/2, который фосфорилирует и ингибирует Myt1, приводя к остановке клеточного цикла в G2/M PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYWxtZXI8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS
ZWNOdW0+NDkxPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzJdPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjQ5MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9Incyd2Z4YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+NDkxPC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QYWxtZXIsIEEuPC9hdXRob3I+PGF1dGhv
cj5HYXZpbiwgQS4gQy48L2F1dGhvcj48YXV0aG9yPk5lYnJlZGEsIEEuIFIuPC9hdXRob3I+PC9h
dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RXVyb3BlYW4gTW9sZWN1bGFyIEJp
b2xvZ3kgTGFib3JhdG9yeSwgTWV5ZXJob2ZzdHJhc3NlIDEsIDY5MTE3IEhlaWRlbGJlcmcsIEdl
cm1hbnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBsaW5rIGJldHdlZW4gTUFQIGtp
bmFzZSBhbmQgcDM0KGNkYzIpL2N5Y2xpbiBCIGR1cmluZyBvb2N5dGUgbWF0dXJhdGlvbjogcDkw
KHJzaykgcGhvc3Bob3J5bGF0ZXMgYW5kIGluYWN0aXZhdGVzIHRoZSBwMzQoY2RjMikgaW5oaWJp
dG9yeSBraW5hc2UgTXl0MTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FTUJPIEo8L3NlY29uZGFy
eS10aXRsZT48YWx0LXRpdGxlPlRoZSBFTUJPIGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FTUJPIEo8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgRU1C
TyBqb3VybmFsPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRs
ZT5FTUJPIEo8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgRU1CTyBqb3VybmFsPC9hYmJyLTE+PC9h
bHQtcGVyaW9kaWNhbD48cGFnZXM+NTAzNy00NzwvcGFnZXM+PHZvbHVtZT4xNzwvdm9sdW1lPjxu
dW1iZXI+MTc8L251bWJlcj48ZWRpdGlvbj4xOTk4LzA5LzAyPC9lZGl0aW9uPjxrZXl3b3Jkcz48
a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkNEQzIgUHJvdGVpbiBLaW5hc2UvIG1l
dGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2FsY2l1bS1DYWxtb2R1bGluLURlcGVuZGVudCBQ
cm90ZWluIEtpbmFzZXMvIG1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBEaWZmZXJl
bnRpYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q3ljbGluIEIvIG1ldGFib2xpc208L2tleXdvcmQ+
PGtleXdvcmQ+RW56eW1lIEFjdGl2YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TW9kZWxzLCBCaW9s
b2dpY2FsPC9rZXl3b3JkPjxrZXl3b3JkPk9vY3l0ZXMvIGN5dG9sb2d5L21ldGFib2xpc208L2tl
eXdvcmQ+PGtleXdvcmQ+UGhvc3Bob3J5bGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlByb3RlaW4g
QmluZGluZzwva2V5d29yZD48a2V5d29yZD5Qcm90ZWluLVNlcmluZS1UaHJlb25pbmUgS2luYXNl
cy8gYW50YWdvbmlzdHMgJmFtcDsgaW5oaWJpdG9yczwva2V5d29yZD48a2V5d29yZD5Qcm90ZWlu
LVR5cm9zaW5lIEtpbmFzZXMvIGFudGFnb25pc3RzICZhbXA7IGluaGliaXRvcnM8L2tleXdvcmQ+
PGtleXdvcmQ+Umlib3NvbWFsIFByb3RlaW4gUzYgS2luYXNlcy8gbWV0YWJvbGlzbTwva2V5d29y
ZD48a2V5d29yZD5TaWduYWwgVHJhbnNkdWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlhlbm9wdXM8
L2tleXdvcmQ+PGtleXdvcmQ+WGVub3B1cyBQcm90ZWluczwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4xOTk4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDE8L2RhdGU+PC9wdWIt
ZGF0ZXM+PC9kYXRlcz48aXNibj4wMjYxLTQxODkgKFByaW50KSYjeEQ7MDI2MS00MTg5IChMaW5r
aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT45NzI0NjM5PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwv
dXJscz48Y3VzdG9tMj5QTUMxMTcwODMxPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51
bT4xMC4xMDkzL2VtYm9qLzE3LjE3LjUwMzc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1v
dGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1
YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYWxtZXI8L0F1dGhvcj48WWVhcj4xOTk4PC9ZZWFyPjxS
ZWNOdW0+NDkxPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxMzJdPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjQ5MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9Incyd2Z4YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+NDkxPC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QYWxtZXIsIEEuPC9hdXRob3I+PGF1dGhv
cj5HYXZpbiwgQS4gQy48L2F1dGhvcj48YXV0aG9yPk5lYnJlZGEsIEEuIFIuPC9hdXRob3I+PC9h
dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RXVyb3BlYW4gTW9sZWN1bGFyIEJp
b2xvZ3kgTGFib3JhdG9yeSwgTWV5ZXJob2ZzdHJhc3NlIDEsIDY5MTE3IEhlaWRlbGJlcmcsIEdl
cm1hbnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBsaW5rIGJldHdlZW4gTUFQIGtp
bmFzZSBhbmQgcDM0KGNkYzIpL2N5Y2xpbiBCIGR1cmluZyBvb2N5dGUgbWF0dXJhdGlvbjogcDkw
KHJzaykgcGhvc3Bob3J5bGF0ZXMgYW5kIGluYWN0aXZhdGVzIHRoZSBwMzQoY2RjMikgaW5oaWJp
dG9yeSBraW5hc2UgTXl0MTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FTUJPIEo8L3NlY29uZGFy
eS10aXRsZT48YWx0LXRpdGxlPlRoZSBFTUJPIGpvdXJuYWw8L2FsdC10aXRsZT48L3RpdGxlcz48
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FTUJPIEo8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgRU1C
TyBqb3VybmFsPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRs
ZT5FTUJPIEo8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgRU1CTyBqb3VybmFsPC9hYmJyLTE+PC9h
bHQtcGVyaW9kaWNhbD48cGFnZXM+NTAzNy00NzwvcGFnZXM+PHZvbHVtZT4xNzwvdm9sdW1lPjxu
dW1iZXI+MTc8L251bWJlcj48ZWRpdGlvbj4xOTk4LzA5LzAyPC9lZGl0aW9uPjxrZXl3b3Jkcz48
a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkNEQzIgUHJvdGVpbiBLaW5hc2UvIG1l
dGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2FsY2l1bS1DYWxtb2R1bGluLURlcGVuZGVudCBQ
cm90ZWluIEtpbmFzZXMvIG1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBEaWZmZXJl
bnRpYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q3ljbGluIEIvIG1ldGFib2xpc208L2tleXdvcmQ+
PGtleXdvcmQ+RW56eW1lIEFjdGl2YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+TW9kZWxzLCBCaW9s
b2dpY2FsPC9rZXl3b3JkPjxrZXl3b3JkPk9vY3l0ZXMvIGN5dG9sb2d5L21ldGFib2xpc208L2tl
eXdvcmQ+PGtleXdvcmQ+UGhvc3Bob3J5bGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlByb3RlaW4g
QmluZGluZzwva2V5d29yZD48a2V5d29yZD5Qcm90ZWluLVNlcmluZS1UaHJlb25pbmUgS2luYXNl
cy8gYW50YWdvbmlzdHMgJmFtcDsgaW5oaWJpdG9yczwva2V5d29yZD48a2V5d29yZD5Qcm90ZWlu
LVR5cm9zaW5lIEtpbmFzZXMvIGFudGFnb25pc3RzICZhbXA7IGluaGliaXRvcnM8L2tleXdvcmQ+
PGtleXdvcmQ+Umlib3NvbWFsIFByb3RlaW4gUzYgS2luYXNlcy8gbWV0YWJvbGlzbTwva2V5d29y
ZD48a2V5d29yZD5TaWduYWwgVHJhbnNkdWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlhlbm9wdXM8
L2tleXdvcmQ+PGtleXdvcmQ+WGVub3B1cyBQcm90ZWluczwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4xOTk4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwIDE8L2RhdGU+PC9wdWIt
ZGF0ZXM+PC9kYXRlcz48aXNibj4wMjYxLTQxODkgKFByaW50KSYjeEQ7MDI2MS00MTg5IChMaW5r
aW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT45NzI0NjM5PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwv
dXJscz48Y3VzdG9tMj5QTUMxMTcwODMxPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51
bT4xMC4xMDkzL2VtYm9qLzE3LjE3LjUwMzc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1v
dGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1
YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA [132]. Для активации комплекса циклин В/CDK1 необходима фосфатаза Cdc25С, которая дефосфорилирует CDK1, убирая ингибирующие фосфаты PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdHJhdXNmZWxkPC9BdXRob3I+PFllYXI+MTk5MTwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdHJhdXNmZWxkPC9BdXRob3I+PFllYXI+MTk5MTwvWWVh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ADDIN EN.CITE.DATA [133, 134]. Активированный циклин В/CDK1 запускает события раннего митоза ADDIN EN.CITE <EndNote><Cite><Author>Solomon</Author><Year>1992</Year><RecNum>255</RecNum><DisplayText>[129]</DisplayText><record><rec-number>255</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">255</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Solomon, M. J.</author><author>Lee, T.</author><author>Kirschner, M. W.</author></authors></contributors><auth-address>Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.</auth-address><titles><title>Role of phosphorylation in p34cdc2 activation: identification of an activating kinase</title><secondary-title>Mol Biol Cell</secondary-title><alt-title>Molecular biology of the cell</alt-title></titles><periodical><full-title>Mol Biol Cell</full-title><abbr-1>Molecular biology of the cell</abbr-1></periodical><alt-periodical><full-title>Mol Biol Cell</full-title><abbr-1>Molecular biology of the cell</abbr-1></alt-periodical><pages>13-27</pages><volume>3</volume><number>1</number><edition>1992/01/01</edition><keywords><keyword>Adenosine Triphosphate/metabolism</keyword><keyword>Animals</keyword><keyword>Antibodies, Monoclonal/immunology</keyword><keyword>Base Sequence</keyword><keyword>Binding Sites</keyword><keyword>CDC2 Protein Kinase/isolation & purification/ metabolism</keyword><keyword>Cyclins/metabolism</keyword><keyword>Enzyme Activation</keyword><keyword>Immunoblotting</keyword><keyword>Mitosis/drug effects</keyword><keyword>Molecular Sequence Data</keyword><keyword>Phosphorylation</keyword><keyword>Vanadates/pharmacology</keyword><keyword>Xenopus laevis</keyword></keywords><dates><year>1992</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1059-1524 (Print)
1059-1524 (Linking)</isbn><accession-num>1532335</accession-num><urls></urls><custom2>PMC275499</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[129]. Параллельно с активацией циклин В/CDK1 происходит ингибирование Wee1 и Myt1. В течение интерфазы Cdc25C-associated protein kinase (C-TAK1) фосфорилируют Cdc25С по Ser216, что способствует его связыванию с белком 14-3-3 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HcmF2ZXM8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HcmF2ZXM8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA [135-137], который удерживает Cdc25С в цитоплазме, препятствуя перемещению фосфатазы в ядро и активации циклин В/CDK1 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZW5nPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVj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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZW5nPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVj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==
ADDIN EN.CITE.DATA [138, 139]. Активирующаяся в ответ на повреждение ДНК Chk1 киназа тоже способна фосфорилировать Cdc25С, приводя к ингибированию фосфатазы и остановке прогрессии клеточного цикла PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZW5nPC9BdXRob3I+PFllYXI+MTk5NzwvWWVhcj48UmVj
TnVtPjI8L1JlY051bT48RGlzcGxheVRleHQ+WzEzOCwgMTQwLCAxNDFdPC9EaXNwbGF5VGV4dD48
cmVjb3JkPjxyZWMtbnVtYmVyPjI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i
RU4iIGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjI8L2tleT48
L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5
cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlBlbmcsIEMuIFkuPC9hdXRob3I+PGF1
dGhvcj5HcmF2ZXMsIFAuIFIuPC9hdXRob3I+PGF1dGhvcj5UaG9tYSwgUi4gUy48L2F1dGhvcj48
YXV0aG9yPld1LCBaLjwvYXV0aG9yPjxhdXRob3I+U2hhdywgQS4gUy48L2F1dGhvcj48YXV0aG9y
«