«Антипролиферативное действие карнозина и его производных на опухолевые клетки нейрального происхождения ...»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ADDIN EN.CITE.DATA [211, 212]. BHMF и RNO представляют собой ловушки синглетного кислорода (1О2), ингибирование окисления ловушек с помощью карнозина указывает на способность карнозина взаимодействовать с 1О2. Кроме того, карнозин снижал интенсивность хемилюминесценции, индуцируемой синглетным кислородом, образующимся в смеси Н2О2+NaClO, подтверждая способность тушить 1О2 ADDIN EN.CITE <EndNote><Cite><Author>Швачко</Author><Year>1990</Year><RecNum>166</RecNum><DisplayText>[213]</DisplayText><record><rec-number>166</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">166</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" charset="204" size="100%">Швачко,</style><style face="normal" font="default" size="100%"> </style><style face="normal" font="default" charset="204" size="100%">А.Г., Формазюк, В.Е., Сергиенко В.И.</style></author></authors></contributors><titles><title><style face="normal" font="default" charset="204" size="100%">Тушение хемилюминесценции синглетного кислорода в присутствии карнозина</style></title></titles><pages><style face="normal" font="default" charset="204" size="100%">155-156</style></pages><dates><year><style face="normal" font="default" charset="204" size="100%">1990</style></year></dates><urls></urls></record></Cite></EndNote>[213]. Интересно отметить, что при эквимолярных концентрациях эффективность тушения 1О2 карнозином была выше, чем у гистидина, известной ловушки для 1О2 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcmF3bjwvQXV0aG9yPjxZZWFyPjE5ODE8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcmF3bjwvQXV0aG9yPjxZZWFyPjE5ODE8L1llYXI+PFJl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ADDIN EN.CITE.DATA [211, 212, 214]. Более высокая эффективность карнозина по сравнению с гистидином, возможно, связана с особенностями внутримолекулярных взаимодействий (влияние -аланина), что приводит к большей реакционной способности гистидина в молекуле карнозина.
Методом синхронной регистрации светопоглощения при радиолизе водного раствора карнозина было выявлено образование комплекса между супероксидом и карнозином с частичным переносом заряда. Образование комплекса приводило к снижению константы скорости дисмутации О2-• и повышению его стабильности в водном растворе ADDIN EN.CITE <EndNote><Cite><Author>Pavlov</Author><Year>1990</Year><RecNum>135</RecNum><DisplayText>[14]</DisplayText><record><rec-number>135</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">135</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pavlov, A. R.</author><author>Revina, A. A.</author><author>Dupin, A. M.</author><author>Boldyrev, A. A.</author><author>Iaropolov, A. I.</author></authors></contributors><titles><title>[Interactions of carnosine and superoxide radicals in aqueous solutions]</title><secondary-title>Biull Eksp Biol Med</secondary-title><alt-title>Biulleten' eksperimental'noi biologii i meditsiny</alt-title></titles><periodical><full-title>Biull Eksp Biol Med</full-title><abbr-1>Biulleten' eksperimental'noi biologii i meditsiny</abbr-1></periodical><alt-periodical><full-title>Biull Eksp Biol Med</full-title><abbr-1>Biulleten' eksperimental'noi biologii i meditsiny</abbr-1></alt-periodical><pages>391-3</pages><volume>110</volume><number>10</number><edition>1990/10/01</edition><keywords><keyword>Carnosine/ chemistry</keyword><keyword>Free Radicals</keyword><keyword>Hydrogen-Ion Concentration</keyword><keyword>Solutions</keyword><keyword>Superoxides/ chemistry</keyword></keywords><dates><year>1990</year><pub-dates><date>Oct</date></pub-dates></dates><orig-pub>Vzaimodeistvie karnozina s superoksidnymi radikalami v vodnykh rastvorov.</orig-pub><isbn>0365-9615 (Print)
0365-9615 (Linking)</isbn><accession-num>2177670</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>rus</language></record></Cite></EndNote>[14]. Способность карнозина взаимодействовать с супероксид анионом была подтверждена в независимой работе Klebanov et al, где карнозин препятствовал восстановлению нитро-голубого тетразолия под действием О2-• образованного в смеси ксантин+ксантиноксидаза ADDIN EN.CITE <EndNote><Cite><Author>Klebanov</Author><Year>1997</Year><RecNum>144</RecNum><DisplayText>[17]</DisplayText><record><rec-number>144</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">144</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Klebanov, G. I.</author><author>Teselkin Yu, O.</author><author>Babenkova, I. V.</author><author>Popov, I. N.</author><author>Levin, G.</author><author>Tyulina, O. V.</author><author>Boldyrev, A. A.</author><author>Vladimirov Yu, A.</author></authors></contributors><auth-address>Russian State Medical University, Moscow, Russia.</auth-address><titles><title>Evidence for a direct interaction of superoxide anion radical with carnosine</title><secondary-title>Biochem Mol Biol Int</secondary-title><alt-title>Biochemistry and molecular biology international</alt-title></titles><periodical><full-title>Biochem Mol Biol Int</full-title><abbr-1>Biochemistry and molecular biology international</abbr-1></periodical><alt-periodical><full-title>Biochem Mol Biol Int</full-title><abbr-1>Biochemistry and molecular biology international</abbr-1></alt-periodical><pages>99-106</pages><volume>43</volume><number>1</number><edition>1997/10/07</edition><keywords><keyword>Carnosine/ metabolism/pharmacology</keyword><keyword>Luminescent Measurements</keyword><keyword>Luminol/metabolism</keyword><keyword>Nitroblue Tetrazolium/metabolism</keyword><keyword>Oxidation-Reduction</keyword><keyword>Superoxides/ metabolism</keyword><keyword>Xanthine Oxidase/metabolism</keyword></keywords><dates><year>1997</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1039-9712 (Print)
1039-9712 (Linking)</isbn><accession-num>9315287</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[17]. Сравнение эффективности тушения О2-•, образующегося в смеси глутатион+пероксидаза+люминол, выявило, что карнозин и гистидин демонстрировали примерно одинаковую эффективность, в то время как -аланин был неактивен, что указывает на определяющую роль гистидина при взаимодействии карнозина с супероксидом PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbGViYW5vdjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbGViYW5vdjwvQXV0aG9yPjxZZWFyPjE5OTg8L1llYXI+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ADDIN EN.CITE.DATA [215].
С помощью метода электронного парамагнитного резонанса (ЭПР) было продемонстрировано, что добавление карнозина к смеси реакции Фентона приводит к формированию продукта способного конкурировать со спиновой ловушкой для OH• - 5,5-диметилпирролин-N-оксидом (DMPO) ADDIN EN.CITE <EndNote><Cite><Author>Chan</Author><Year>1994</Year><RecNum>145</RecNum><DisplayText>[16, 216]</DisplayText><record><rec-number>145</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">145</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chan, W. K. M., </author><author>Decker, E. A., </author><author>Lee, J. B., </author><author>Butterfield, D. A. </author></authors></contributors><titles><title>EPR spin-trapping studies of the hydroxyl radical scavenging activity of carnosine and related dipeptides</title><secondary-title>J Agric Food Chem</secondary-title></titles><periodical><full-title>J Agric Food Chem</full-title><abbr-1>Journal of agricultural and food chemistry</abbr-1></periodical><pages>1407-1410</pages><volume>42</volume><dates><year>1994</year></dates><urls></urls></record></Cite><Cite><Author>RUBTSOV</Author><Year>1991</Year><RecNum>171</RecNum><record><rec-number>171</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">171</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>RUBTSOV, AM</author><author>SCHARA, M.</author><author>SENTJURC, M.</author><author>BOLDYREV, AA</author></authors></contributors><titles><title>HYDROXYL RADICAL-SCAVENGING ACTIVITY OF CARNOSINE - A SPIN TRAPPING STUDY</title><secondary-title>Acta Pharmaceutica Jugoslavika</secondary-title></titles><periodical><full-title>Acta Pharmaceutica Jugoslavika</full-title></periodical><pages>401-407</pages><volume>41</volume><number>4</number><dates><year>1991</year></dates><label>boldyrev1991hydroxyl1978455</label><work-type>journal article</work-type><urls><related-urls><url>http://istina.msu.ru/publications/article/1978455/</url></related-urls></urls></record></Cite></EndNote>[16, 216]. Гистидин и гомокарнозин взаимодействовали с OH• менее эффективно, чем карнозин. Образование комплексов OH• с -аланином и ГАМК обнаружено не было. Интересно отметить, что эффективность связывания OH• в смеси -аланин+гистидин была ниже, чем в присутствии карнозина, что еще раз подтверждает важную роль внутримолекулярных взаимодействий для антиоксидантного эффекта карнозина ADDIN EN.CITE <EndNote><Cite><Author>Chan</Author><Year>1994</Year><RecNum>145</RecNum><DisplayText>[16]</DisplayText><record><rec-number>145</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">145</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chan, W. K. M., </author><author>Decker, E. A., </author><author>Lee, J. B., </author><author>Butterfield, D. A. </author></authors></contributors><titles><title>EPR spin-trapping studies of the hydroxyl radical scavenging activity of carnosine and related dipeptides</title><secondary-title>J Agric Food Chem</secondary-title></titles><periodical><full-title>J Agric Food Chem</full-title><abbr-1>Journal of agricultural and food chemistry</abbr-1></periodical><pages>1407-1410</pages><volume>42</volume><dates><year>1994</year></dates><urls></urls></record></Cite></EndNote>[16].
В ряде работ были продемонстрированы способности карнозина взаимодействовать с продуктами ПОЛ, препятствуя распространению окислительного повреждения. Карнозин сдерживал накопление малонового альдегида, образующегося в результате окисления фрагментов саркоплазматического ретикулума, и способствовал сохранению функций мембран ADDIN EN.CITE <EndNote><Cite><Author>Dupin</Author><Year>1984</Year><RecNum>113</RecNum><DisplayText>[18]</DisplayText><record><rec-number>113</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">113</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dupin, A.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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2hlbjwvQXV0aG9yPjxZZWFyPjE5ODg8L1llYXI+PFJl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ADDIN EN.CITE.DATA [15]. С использованием внеклеточных систем Zhou и Decker наглядно продемонстрировали взаимодействие карнозина с ненасыщенными альдегидами (транс-2-гексеналь, транс-2-ноненаль), а также 4-гидроксиноненалем – опасным продуктом повреждающим ДНК PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb2xpPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb2xpPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA [19, 217]. Гистидин и имидазол также демонстрировали защитное действие, в то время как -аланин и ГАМК не оказывали какого либо эффекта PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2hlbjwvQXV0aG9yPjxZZWFyPjE5ODg8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2hlbjwvQXV0aG9yPjxZZWFyPjE5ODg8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA [15, 19].
Одним из проявлений антиоксидантных свойств карнозина является его радиомодифицирующий эффект. Повреждающее действие ионизирующего излучения связано, главным образом, с развитием мощнейшего окислительного стресса в результате радиолиза воды. Пероральное введение мышам карнозина в течение 20 суток перед облучением способствовало повышению выживаемости животных ADDIN EN.CITE <EndNote><Cite><Author>Северин С. Е.</Author><Year>1990</Year><RecNum>167</RecNum><DisplayText>[218]</DisplayText><record><rec-number>167</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">167</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" charset="204" size="100%">Северин С. Е., Болдырев А. А., Стволинский С. Л., Бордюков, М.М., Гончаренко, Е.Н., Деев, Л.И., Малинина, И.Е., Кудряшов, Ю.Е. </style></author></authors></contributors><titles><title><style face="normal" font="default" charset="204" size="100%">О радиомодифицирующих свойствах карнозина</style></title><secondary-title><style face="normal" font="default" charset="204" size="100%">Радиобиология</style></secondary-title></titles><periodical><full-title>Радиобиология</full-title></periodical><pages><style face="normal" font="default" charset="204" size="100%">765-768</style></pages><volume><style face="normal" font="default" charset="204" size="100%">30</style></volume><number><style face="normal" font="default" charset="204" size="100%">6</style></number><dates><year><style face="normal" font="default" charset="204" size="100%">1990</style></year></dates><urls></urls></record></Cite></EndNote>[218]. Радиомодифицирующее действие карнозина было подтверждено с помощью метода эндогенных селезеночных колоний. Было обнаружено увеличение эффективности образования колоний гематопоэтическими стволовыми клетками из костного мозга мышей, которым перед облучением вводили карнозин, по сравнению с контрольными животными PEVuZE5vdGU+PENpdGU+PEF1dGhvcj7QmtGD0YDQtdC70LvQsDwvQXV0aG9yPjxZZWFyPjE5OTE8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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj7QmtGD0YDQtdC70LvQsDwvQXV0aG9yPjxZZWFyPjE5OTE8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ADDIN EN.CITE.DATA [219, 220]. 1.3.3. Эффект карнозина и его производных на пролиферацию нормальных и опухолевых клетокПродолжительное культивирование нормальных человеческих фибробластов с карнозином (10 - 50 мМ) приводило к удлинению продолжительности жизни клеток, что выражалось в увеличении количества популяционных удвоений, т.н. предела Хейфлика ADDIN EN.CITE <EndNote><Cite><Author>Hayflick</Author><Year>1965</Year><RecNum>226</RecNum><DisplayText>[221]</DisplayText><record><rec-number>226</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">226</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hayflick, L.</author></authors></contributors><titles><title>THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS</title><secondary-title>Exp Cell Res</secondary-title><alt-title>Experimental cell research</alt-title></titles><periodical><full-title>Exp Cell Res</full-title><abbr-1>Experimental cell research</abbr-1></periodical><alt-periodical><full-title>Exp Cell Res</full-title><abbr-1>Experimental cell research</abbr-1></alt-periodical><pages>614-36</pages><volume>37</volume><edition>1965/03/01</edition><keywords><keyword>Aging</keyword><keyword>Cell Division</keyword><keyword>Chromosome Aberrations</keyword><keyword>Fetus</keyword><keyword>Lung</keyword><keyword>Tissue Culture Techniques</keyword></keywords><dates><year>1965</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0014-4827 (Print)
0014-4827 (Linking)</isbn><accession-num>14315085</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[221]. Кроме того, отмечали задержку развития старческого фенотипа в виде усиления зернистости и потери вытянутой фибробластоподобной формы ADDIN EN.CITE <EndNote><Cite><Author>McFarland</Author><Year>1994</Year><RecNum>162</RecNum><DisplayText>[22]</DisplayText><record><rec-number>162</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">162</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarland, G. A.</author><author>Holliday, R.</author></authors></contributors><auth-address>CSIRO Division of Biomolecular Engineering, Sydney Laboratory, NSW, Australia.</auth-address><titles><title>Retardation of the senescence of cultured human diploid fibroblasts by carnosine</title><secondary-title>Exp Cell Res</secondary-title><alt-title>Experimental cell research</alt-title></titles><periodical><full-title>Exp Cell Res</full-title><abbr-1>Experimental cell research</abbr-1></periodical><alt-periodical><full-title>Exp Cell Res</full-title><abbr-1>Experimental cell research</abbr-1></alt-periodical><pages>167-75</pages><volume>212</volume><number>2</number><edition>1994/06/01</edition><keywords><keyword>Carnosine/ pharmacology</keyword><keyword>Cell Aging/ drug effects</keyword><keyword>Fibroblasts</keyword><keyword>Humans</keyword></keywords><dates><year>1994</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0014-4827 (Print)
0014-4827 (Linking)</isbn><accession-num>8187813</accession-num><urls></urls><electronic-resource-num>10.1006/excr.1994.1132</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[22]. Добавление карнозина к клеткам долгое время культивируемым на среде без карнозина приводило к обращению старческого фенотипа и способствовало увеличению продолжительности их жизни в сравнении с контролем. Удаление карнозина из среды нивелировало описанный эффект ADDIN EN.CITE <EndNote><Cite><Author>McFarland</Author><Year>1999</Year><RecNum>161</RecNum><DisplayText>[222]</DisplayText><record><rec-number>161</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">161</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarland, G. A.</author><author>Holliday, R.</author></authors></contributors><auth-address>CSIRO Division of Molecular Science, Sydney Laboratory, North Ryde, Australia.</auth-address><titles><title>Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts</title><secondary-title>Exp Gerontol</secondary-title><alt-title>Experimental gerontology</alt-title></titles><periodical><full-title>Exp Gerontol</full-title><abbr-1>Experimental gerontology</abbr-1></periodical><alt-periodical><full-title>Exp Gerontol</full-title><abbr-1>Experimental gerontology</abbr-1></alt-periodical><pages>35-45</pages><volume>34</volume><number>1</number><edition>1999/04/10</edition><keywords><keyword>Carnosine/ pharmacology</keyword><keyword>Cell Adhesion/drug effects</keyword><keyword>Cell Aging/ drug effects</keyword><keyword>Cell Division/drug effects</keyword><keyword>Cells, Cultured</keyword><keyword>Fibroblasts/drug effects/physiology</keyword><keyword>Humans</keyword></keywords><dates><year>1999</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0531-5565 (Print)
0531-5565 (Linking)</isbn><accession-num>10197726</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[222]. Карнозин также способствовал увеличению эффективности посева фибробластов. При посеве клеток в низких разведениях, в чашках инкубируемых с карнозином образовывалось больше колоний, чем в контрольных, что указывает на активацию пролиферативных процессов фибробластов под действием карнозина ADDIN EN.CITE <EndNote><Cite><Author>McFarland</Author><Year>1999</Year><RecNum>161</RecNum><DisplayText>[222]</DisplayText><record><rec-number>161</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">161</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarland, G. A.</author><author>Holliday, R.</author></authors></contributors><auth-address>CSIRO Division of Molecular Science, Sydney Laboratory, North Ryde, Australia.</auth-address><titles><title>Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts</title><secondary-title>Exp Gerontol</secondary-title><alt-title>Experimental gerontology</alt-title></titles><periodical><full-title>Exp Gerontol</full-title><abbr-1>Experimental gerontology</abbr-1></periodical><alt-periodical><full-title>Exp Gerontol</full-title><abbr-1>Experimental gerontology</abbr-1></alt-periodical><pages>35-45</pages><volume>34</volume><number>1</number><edition>1999/04/10</edition><keywords><keyword>Carnosine/ pharmacology</keyword><keyword>Cell Adhesion/drug effects</keyword><keyword>Cell Aging/ drug effects</keyword><keyword>Cell Division/drug effects</keyword><keyword>Cells, Cultured</keyword><keyword>Fibroblasts/drug effects/physiology</keyword><keyword>Humans</keyword></keywords><dates><year>1999</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0531-5565 (Print)
0531-5565 (Linking)</isbn><accession-num>10197726</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[222]. Позже Shao et al. продемонстрировали замедление скорости укорачивания теломер и снижение количества дефектов в ДНК теломер под действием карнозина PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGFvPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48UmVj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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGFvPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48UmVj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 EN.CITE.DATA [223]. Укорачивание теломер представляется одним из основных факторов ограничивающий количество клеточных делений ADDIN EN.CITE <EndNote><Cite><Author>Levy</Author><Year>1992</Year><RecNum>227</RecNum><DisplayText>[224]</DisplayText><record><rec-number>227</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">227</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Levy, M. Z.</author><author>Allsopp, R. C.</author><author>Futcher, A. B.</author><author>Greider, C. W.</author><author>Harley, C. B.</author></authors></contributors><auth-address>Department of Biochemistry, McMaster University Hamilton, Ontario, Canada.</auth-address><titles><title>Telomere end-replication problem and cell aging</title><secondary-title>J Mol Biol</secondary-title><alt-title>Journal of molecular biology</alt-title></titles><periodical><full-title>J Mol Biol</full-title><abbr-1>Journal of molecular biology</abbr-1></periodical><alt-periodical><full-title>J Mol Biol</full-title><abbr-1>Journal of molecular biology</abbr-1></alt-periodical><pages>951-60</pages><volume>225</volume><number>4</number><edition>1992/06/20</edition><keywords><keyword>Adult</keyword><keyword>Base Sequence</keyword><keyword>Cell Division</keyword><keyword>Cells, Cultured</keyword><keyword>Chromosome Deletion</keyword><keyword>Chromosomes, Human/ physiology</keyword><keyword>DNA/genetics/ metabolism</keyword><keyword>DNA Replication</keyword><keyword>Fibroblasts/cytology/physiology</keyword><keyword>Humans</keyword><keyword>Kinetics</keyword><keyword>Models, Genetic</keyword><keyword>Oligonucleotide Probes</keyword><keyword>Repetitive Sequences, Nucleic Acid</keyword><keyword>Skin Physiological Phenomena</keyword><keyword>Telomere/ physiology</keyword></keywords><dates><year>1992</year><pub-dates><date>Jun 20</date></pub-dates></dates><isbn>0022-2836 (Print)
0022-2836 (Linking)</isbn><accession-num>1613801</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[224], замедление этого процесса может быть одним из механизмов удлинения предела Хейфлика и задержки формирования старческого фенотипа с помощью карнозина.
В 1986 году, японские ученые Nagai и Suda впервые описали эффект карнозина на опухолевый клетки, который в корне отличался от действия карнозина на нормальные клетки. Подкожные инъекции карнозина мышам линии ddY, которым предварительно вживляли клетки саркомы, способствовали снижению интенсивности пролиферации опухолевых клеток и увеличивали выживаемость животных ADDIN EN.CITE <EndNote><Cite><Author>Nagai</Author><Year>1986</Year><RecNum>88</RecNum><DisplayText>[20]</DisplayText><record><rec-number>88</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">88</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Nagai, K.</author><author>Suda, T.</author></authors></contributors><titles><title>[Antineoplastic effects of carnosine and beta-alanine--physiological considerations of its antineoplastic effects]</title><secondary-title>Nihon Seirigaku Zasshi</secondary-title><alt-title>Nihon seirigaku zasshi. Journal of the Physiological Society of Japan</alt-title></titles><periodical><full-title>Nihon Seirigaku Zasshi</full-title><abbr-1>Nihon seirigaku zasshi. Journal of the Physiological Society of Japan</abbr-1></periodical><alt-periodical><full-title>Nihon Seirigaku Zasshi</full-title><abbr-1>Nihon seirigaku zasshi. Journal of the Physiological Society of Japan</abbr-1></alt-periodical><pages>741-7</pages><volume>48</volume><number>11</number><edition>1986/01/01</edition><keywords><keyword>Alanine/ pharmacology</keyword><keyword>Animals</keyword><keyword>Antineoplastic Agents</keyword><keyword>Carnosine/administration & dosage/ pharmacology/therapeutic use</keyword><keyword>Dipeptides/ pharmacology</keyword><keyword>Male</keyword><keyword>Mice</keyword><keyword>Mitomycin</keyword><keyword>Mitomycins/administration & dosage</keyword><keyword>Picibanil/administration & dosage</keyword><keyword>Sarcoma 180/drug therapy</keyword><keyword>beta-Alanine/administration & dosage/ pharmacology/therapeutic use</keyword></keywords><dates><year>1986</year></dates><isbn>0031-9341 (Print)
0031-9341 (Linking)</isbn><accession-num>3102721</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>jpn</language></record></Cite></EndNote>[20]. В независимом исследовании Renner et al. на мышах с ксенографами HER2/neu NIH3T3 фибробластов показали, что ежедневные внутрибрюшинные инъекции карнозина существенно подавляют пролиферацию злокачественных клеток и опухолевый рост. Снижение скорости пролиферации опухолевых клеток под действием карнозина сопровождалось снижением синтеза АФК и активности лактатдегидрогеназы (ЛДГ). Кроме того, в опухолях мышей, которым делали инъекции карнозина карнозина было обнаружено меньшее количество митозов, чем у контрольных животных PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZW5uZXI8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SZW5uZXI8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA [21]. Сходные изменения наблюдали в первичной культуре клеток мультиформной глиобластомы (Glioblastoma multiforme). Обработка клеток карнозином (20-50 мМ) в течение 4 дней приводила к уменьшению внутриклеточного уровня АТФ и ЛДГ, а также к снижению синтеза ДНК ADDIN EN.CITE <EndNote><Cite><Author>Renner</Author><Year>2008</Year><RecNum>91</RecNum><DisplayText>[208]</DisplayText><record><rec-number>91</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">91</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Renner, C., Seyffarth, A., Garcia de Arriba, S., Meixensberger, J., Gebhardt, R., Gaunitz, F.</author></authors></contributors><titles><title>Carnosine Inhibits Growth of Cells Isolated from Human Glioblastoma Multiforme</title><secondary-title>International Journal of Peptide Research and Therapeutics </secondary-title></titles><periodical><full-title>International Journal of Peptide Research and Therapeutics</full-title></periodical><pages>127-135</pages><volume>14</volume><section>127</section><dates><year>2008</year></dates><urls></urls></record></Cite></EndNote>[208]. Ингибирование митохондриального дыхания с помощью KCN в клетках обработанных карнозином не влияло на выработку АТФ или выживаемость клеток. Обработка клеток глиобластомы оксаматом – ингибитором ЛДГ – приводила к резкому снижению концентрации АТФ, при этом карнозин приводил к дальнейшему снижению концентрации АТФ. Исходя из полученных данных авторами был сделан вывод о том, что карнозин индуцирует изменения на уровне гликолиза, которые приводят к ингибированию клеточной пролиферации ADDIN EN.CITE <EndNote><Cite><Author>Renner</Author><Year>2010</Year><RecNum>71</RecNum><DisplayText>[225]</DisplayText><record><rec-number>71</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">71</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Renner, C.</author><author>Asperger, A.</author><author>Seyffarth, A.</author><author>Meixensberger, J.</author><author>Gebhardt, R.</author><author>Gaunitz, F.</author></authors></contributors><auth-address>Klinik und Poliklinik fur Neurochirurgie, Medizinische Fakultat der Universitat Leipzig, Leipzig, Germany.</auth-address><titles><title>Carnosine inhibits ATP production in cells from malignant glioma</title><secondary-title>Neurol Res</secondary-title><alt-title>Neurological research</alt-title></titles><periodical><full-title>Neurol Res</full-title><abbr-1>Neurological research</abbr-1></periodical><alt-periodical><full-title>Neurol Res</full-title><abbr-1>Neurological research</abbr-1></alt-periodical><pages>101-5</pages><volume>32</volume><number>1</number><edition>2009/11/17</edition><keywords><keyword>Adenosine Triphosphate/ metabolism</keyword><keyword>Antineoplastic Agents/ pharmacology</keyword><keyword>Carnosine/ pharmacology</keyword><keyword>Cell Line, Tumor</keyword><keyword>Cells, Cultured</keyword><keyword>Glioma/ drug therapy/ metabolism</keyword><keyword>Glucose/metabolism</keyword><keyword>Glycolysis/drug effects</keyword><keyword>Humans</keyword><keyword>Mitochondria/drug effects/metabolism</keyword><keyword>Organic Chemicals/pharmacology</keyword><keyword>Potassium Cyanide/pharmacology</keyword></keywords><dates><year>2010</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1743-1328 (Electronic)
0161-6412 (Linking)</isbn><accession-num>19909581</accession-num><urls></urls><electronic-resource-num>10.1179/016164109x12518779082237</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[225]. Holliday и McFarland наглядно продемонстрировали избирательность ингибирующего эффекта карнозина на рост опухолевых клеток PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xsaWRheTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xsaWRheTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+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ADDIN EN.CITE.DATA [23, 226]. Добавление карнозина к смеси опухолевых клеток (HeLa) и нормальных человеческих фибробластов (MRC-5) приводило к выборочному уничтожению опухолевых HeLa клеток и способствовало удлинению продолжительности жизни фибробластов ADDIN EN.CITE <EndNote><Cite><Author>Holliday</Author><Year>1996</Year><RecNum>73</RecNum><DisplayText>[23]</DisplayText><record><rec-number>73</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">73</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Holliday, R.</author><author>McFarland, G. A.</author></authors></contributors><auth-address>CSIRO Division of Biomolecular Engineering, Sydney Laboratory, NSW, Australia.</auth-address><titles><title>Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine</title><secondary-title>Br J Cancer</secondary-title><alt-title>British journal of cancer</alt-title></titles><periodical><full-title>Br J Cancer</full-title><abbr-1>British journal of cancer</abbr-1></periodical><alt-periodical><full-title>Br J Cancer</full-title><abbr-1>British journal of cancer</abbr-1></alt-periodical><pages>966-71</pages><volume>73</volume><number>8</number><edition>1996/04/01</edition><keywords><keyword>Animals</keyword><keyword>Antineoplastic Agents/ pharmacology</keyword><keyword>Carnosine/ pharmacology</keyword><keyword>Cell Line, Transformed</keyword><keyword>Culture Media</keyword><keyword>Glycolysis/drug effects</keyword><keyword>HeLa Cells</keyword><keyword>Humans</keyword><keyword>Pyruvates/metabolism</keyword><keyword>Pyruvic Acid</keyword><keyword>Simian virus 40</keyword><keyword>Tumor Cells, Cultured</keyword></keywords><dates><year>1996</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0007-0920 (Print)
0007-0920 (Linking)</isbn><accession-num>8611433</accession-num><urls></urls><custom2>PMC2075811</custom2><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[23]. Интересно отметить, что действие карнозина на две активно пролиферирующие культуры – эмбриональные стволовые (ЭС) клетки мыши и иммортальные клетки эмбриональной терато-карциномы (ЭК) мыши также было различно. Карнозин препятствовал росту злокачественных ЭК-клеток, не затрагивая роста ЭС-клеток ADDIN EN.CITE <EndNote><Cite><Author>McFarland</Author><Year>1999</Year><RecNum>160</RecNum><DisplayText>[226]</DisplayText><record><rec-number>160</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">160</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McFarland, G.</author><author>Holliday, R.</author></authors></contributors><titles><title>Differential response of embryonic stem cells and teratocarcinoma cells to carnosine</title><secondary-title>In Vitro Cell Dev Biol Anim</secondary-title><alt-title>In vitro cellular & developmental biology. Animal</alt-title></titles><periodical><full-title>In Vitro Cell Dev Biol Anim</full-title><abbr-1>In vitro cellular & developmental biology. Animal</abbr-1></periodical><alt-periodical><full-title>In Vitro Cell Dev Biol Anim</full-title><abbr-1>In vitro cellular & developmental biology. Animal</abbr-1></alt-periodical><pages>15-6</pages><volume>35</volume><number>1</number><edition>1999/09/04</edition><keywords><keyword>Animals</keyword><keyword>Carnosine/ pharmacology</keyword><keyword>Cell Division/drug effects</keyword><keyword>Embryo, Mammalian</keyword><keyword>Mice</keyword><keyword>Stem Cells/ drug effects/metabolism</keyword><keyword>Teratocarcinoma/ metabolism</keyword></keywords><dates><year>1999</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>1071-2690 (Print)
1071-2690 (Linking)</isbn><accession-num>10475249</accession-num><urls></urls><electronic-resource-num>10.1007/s11626-999-0037-1</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[226]. Полученные данные указывали на то, что ни степень дифференцировки, ни скорость пролиферации клеток не являются определяющими факторами избирательного действия карнозина на опухолевые клетки.
Количественный анализ экспрессии белков в клетках глиобластомы в контроле и после обработки карнозином выявил изменения в экспрессии 31 белка под действием карнозина, в том числе: Von Hippel–Lindau binding protein 1 (VBP1), BCL2-associated athanogene 2 (BAG2), GrpE-like protein chaperone (GrpEL), transaldolase 1 (TALDO), uroporphyrinogen decarboxylase (UROD) и Obg-like ATPase 1 (OLA1) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc3BlcmdlcjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc3BlcmdlcjwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE.DATA [227]. Интересно отметить, что VBP1, BAG2 и GrpEL участвуют в регуляции активности Hypoxia-inducible factor 1 (HIF-1) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uc3VjaGl5YTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uc3VjaGl5YTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+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ADDIN EN.CITE.DATA [227-230], а BAG2 и GrpEL вовлечены в регуляцию активности белков теплового шока (Heat shock protein 70, Hsp70) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Cb3JnZXM8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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